Interleukin 28B Polymorphisms and Hepatitis C—Translating the Association into Clinical Decision Making
نویسندگان
چکیده
منابع مشابه
Lack of association between interleukin 28B polymorphisms and spontaneous viral clearance in hepatitis B virus patients.
TO THE EDITOR—We read the article by Seto et al [1] with interest. The authors investigated the correlation of HLA-DP and interleukin 28B (IL-28B) polymorphisms with hepatitis B surface antigen (HBsAg) seroclearance in hepatitis B virus (HBV) patients, and found that IL-28B haplotype CG (rs12979860/rs8099917) was associated with HBsAg clearance. The role of IL-28B polymorphisms in HBV has been ...
متن کاملDo interleukin-28B single nucleotide polymorphisms influence the natural history of chronic hepatitis B?
Results A total of 49 cases fit the inclusion criteria. Most were male (90%), with a median (IQR) age of 42.6 (39-46.7) years-old. Eighteen (36.7%) were or had been chronic infected by HCV. Among HBsAg+ patients, 19 (41.3%) were HBeAg+ and 13 (26.5%) were superinfected by the hepatitis delta virus (HDV). No differences were found in the distribution of CC genotypes when comparing patients with ...
متن کاملAssociation of interleukin-28B polymorphisms with platelet count and liver function recovery after liver transplant
The present genome-wide association study investigated the relationship of interleukin 28B (IL-28B) genetic variants with HBV susceptibility and prognosis of HBV-infected patients. This study aims to examine the role of IL-28B polymorphisms on transplant etiologies and the liver function recovery in Chinese liver transplant recipients.A total of 231 liver transplant recipients were enrolled in ...
متن کاملRole of Interleukin-28B Genetic Polymorphisms in Korean Patients with Hepatitis C Virus Infection
BACKGROUND/AIMS This study investigated the role of single nucleotide polymorphisms (SNPs) near the interleukin-28B (IL28B) gene with respect to clinical outcomes and the antiviral response in hepatitis C virus (HCV) infection to suggest the practical utility of IL28B genotyping in Korea. METHODS Two SNPs near IL28B, rs12979860 and rs8099917, were analyzed using an allelic discrimination assa...
متن کاملIntegrating clinical research into clinical decision making.
Evidence-based medicine has placed a general priority on knowledge gained from clinical research for clinical decision making. However, knowledge derived from empiric, population-based research, while valued for its ability to limit bias, is not directly applicable to the care of individual patients. The gap between clinical research and individual patient care centers on the fact that empiric ...
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ژورنال
عنوان ژورنال: Journal of Clinical and Experimental Hepatology
سال: 2011
ISSN: 0973-6883
DOI: 10.1016/s0973-6883(11)60115-1